Long term effects of using modafinil on cognition

Does modafinil damage the brain?

MD 300 mg/kg increased lipid damage in the amygdala, hippocampus, and striatum. Besides, MD increased protein damage in the prefrontal cortex, amygdala, and hippocampus; however, this effect varies depending on the dose administered.

Does modafinil have long-term effects?

“If somebody takes modafinil long-term, they may develop some of the same deficits in slow-wave sleep as cocaine users,” he says. “Slow-wave sleep is the deep sleep that we tend to get early in the night.

Does modafinil improve cognitive function?

What emerged was that the longer and more complex the task tested, the more consistently modafinil conferred cognitive benefits. Modafinil made no difference to working memory, or flexibility of thought, but did improve decision-making and planning.

Does modafinil cause memory loss?

A low dose of pre-training modafinil (0.75 mg/kg) enhanced memory of contextual fear conditioning (tested off-drug one week later) while a high dose (75 mg/kg) disrupted memory.

Does modafinil affect GABA?

Modafinil also has consistent effects on central glutamate and GABA neurotransmitter systems. It increases extracellular glutamate in the thalamus, and at higher doses, in the hippocampus (Ferraro et al, 1997a) and striatum (Ferraro et al, 1998).

Does modafinil deplete dopamine?

Microdialysis studies have also reported that modafinil increases extracellular dopamine. In addition, a recent imaging study in anesthetized monkeys documented significant occupancy of dopamine transporters by intravenously administered modafinil.

Can you take Provigil long-term?

Taking Provigil long-term may increase the risk of developing psychological and physical dependence. However, this side effect seems to be rare, and may be more likely when the drug is used in high doses, or if it’s misused or abused. Provigil abuse is not common.

What is fuzzy brain?

What is brain fog? While it’s not a medical term, brain fog describes a feeling that you don’t have full mental clarity—maybe you’re having trouble remembering something or difficulty focusing on a thought or idea.

Can you take modafinil everyday?

The recommended dose for modafinil is 200mg taken once daily [23]. Modafinil has been found to be well-tolerated, with a low incidence of adverse effects and low potential for abuse [24].

Does modafinil weaken immune system?

Modafinil acts on resident glial cells and infiltrating immune cells, negatively affecting both innate and adaptive immune responses in the brain.

Can modafinil cause psychosis?

Clinicians should be aware that modafinil may induce psychosis with positive symptoms when used for negative symptoms of schizophrenia.

How long does it take for modafinil to get out of your system?

The times for the unchanged modafinil to reach peak concentration in the urine of the three volunteers were at 2 h (6.14 microg/mL), 4 h (9.93 microg/mL) and 8 h (3.58 microg/mL), respectively. Total clearance occurred in approximately 48-72 h with 2-5% eliminated through urine as unchanged modafinil.

How long does modafinil stay in your system Reddit?

Most Modafinil is excreted as one of two major circulating metabolites: modafinil acid or modafinil sulfone. Modafinil and its metabolites may be present at testable levels in the urine for up to 30 hours following ingestion.

Does the military test for modafinil?

If you are a servicemember and you take a drug (such as Modafinil and Adderall) without a prescription, then you will fail a urinalysis test.

What is the difference between Armodafinil and modafinil?

Armodafinil may have a longer half-life compared to modafinil (brand-name Provigil). In some cases, armodafinil may be considered a stronger drug with better wakefulness effects. While both drugs can have similar side effects, some side effects may be more common in one drug versus the other.

What is stronger modafinil or armodafinil?

]. Armodafinil 150 mg was comparable to modafinil 200 mg, which indicates that armodafinil is 1.33 time more potent than racemic modafinil. The use of R-enantiomer of modafinil avoids unnecessary use of S-isomer and exerts less metabolic load on the body.

How much caffeine is equivalent to modafinil?


A dose of modafinil is about as strong as 600mg of caffeine [2] the equivalent of about two grande coffees, but does not induce the shakiness, feelings of anxiety, or frequent trips to the bathroom that excessive caffeine can.

Which is better Provigil or Nuvigil?

It appears to be similarly effective, according to randomized trials, but Nuvigil and Provigil / modafinil have never been directly compared. Because of the longer half-life and the once-a-day dosing, Nuvigil is a good first-line choice, starting at a dose of 150 mg.

Is Provigil habit forming?

Provigil is a controlled substance and can be habit-forming. Patients who must be on it long term should be monitored closely for signs of dependence or abuse.

Why is Provigil a controlled substance?

PROVIGIL is a federally controlled substance (C-IV) because it can be abused or lead to dependence. Keep PROVIGIL in a safe place to prevent misuse and abuse. Selling or giving away PROVIGIL may harm others, and is against the law.

Can you take modafinil as needed?

Adults and teenagers 17 years of age and older—200 milligrams (mg) once a day, in the morning. Your doctor may increase your dose as needed. Teenagers and children younger than 17 years of age—Use and dose must be determined by your doctor.

Can you drink coffee with modafinil?

Take Modafinil to minimize excessive caffeine consumption (for instance, one can consume coffee, tea, colas, chocolate and herbal supplements while taking the drug). For the best results, try to avoid purchasing additional caffeine-containing medicines.

Who should not take modafinil?

You should not use this medicine if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil). To make sure modafinil is safe for you, tell your doctor if you have: angina (chest pain);