Is tianeptine addictive?

Why is tianeptine so addictive?

Supposedly, Tianeptine, in contrast to other anti-depressants, stimulates release of neurotransmitter dopamine in nucleus Accumbens, that probably determine addictive potential of this drug.

Is tianeptine habit forming?

How addictive is tianeptine? There are studies showing high potential for addiction to tianeptine when it is misused for its opioid like properties. Prolonged misuse of tianeptine at high doses is known to cause withdrawal symptoms consistent with other opioid drugs or potentially worse.

Does tianeptine get you high?

At a standard dose, people who take tianeptine don’t get a high, build up tolerance, or have withdrawal symptoms if they stop. Tianeptine hasn’t been considered for approval as an antidepressant in the United States because it’s a generic and therefore not a promising money-maker.

What are the withdrawal symptoms of tianeptine?

Tianeptine dependence and a withdrawal syndrome of anxiety, sweating, myalgias, chills, and depression have been described (2).

How long does tianeptine last?

Its elimination half-life is 2.5 to 3 hours. The elimination half-life has been found to be increased to 4 to 9 hours in the elderly. The drug has an active metabolite, with a much longer elimination half-life of approximately 7.6 hours, leading to a steady-state after about a week.

What does tianeptine do to your body?

Tianeptine affects brain chemicals. It seems to affect mood when used in low doses. In higher doses, it works like an opioid and can cause addiction and other serious side effects. It can also cause withdrawal.

Does tianeptine help you sleep?

This antidepressant agent neither inhibited paradoxical sleep nor increased slow wave sleep. However, tianeptine induced a slight, but significant increase in wakefulness during the first hour following its administration, and had no sedative effects.

Can you buy tianeptine over the counter?

Selling it as a supplement is illegal, but tianeptine is widely available online even now. Numerous studies have found tianeptine is a hazard to public health and may be a risk for abuse, overdose and addiction. Yet the U.S. Food and Drug Administration has only recently taken any action against sellers.

How strong is tianeptine?

Tianeptine is available in tablet, capsule, and powder form and is accessible from online commercial sources under the rubric of nootropics. Ingestion of amounts (250-1,000 mg) exceeding the recommended daily antidepressant dose (37.5 mg) has been advocated on internet blogs6,7 to achieve opioid-like effects.

Is methadone an opiod?

Methadone is a synthetic opioid agonist that eliminates withdrawal symptoms and relieves drug cravings by acting on opioid receptors in the brain—the same receptors that other opioids such as heroin, morphine, and opioid pain medications activate.

What class of drug is tianeptine?

Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants 1. Tianeptine was discovered and patented by The French Society of Medical Research in the 1960s 29.

Is tianeptine legal in Texas?

In Texas, a couple alleged that their son had died as a result of taking the drug. Now, emails obtained by Consumer Reports reveal that the Food and Drug Administration at the time was also looking into the dangers of tianeptine, which is used as a dietary supplement ingredient despite being illegal.

What drug is ZaZa?


Tianeptine is known as ZaZa and Tianna Red by users, who were able to find it readily available in gas stations. In their Clinical Toxicology paper, Rushton and colleagues reported on 48 cases of tianeptine toxicity — overdoses and withdrawal — between Jan. 1, 2015 and March 15, 2020.

Can you fail a drug test for tianeptine?

This supplement contains Tianeptine and it has been linked to reports of overdose and even death. The problem is, it doesn’t show up on a drug screen.

Is tianeptine legal in Alabama?

Law enforcement across Alabama are working to tell store owners that tianeptine is no longer legal is Alabama. A new state law bans the drug, commonly sold in gas stations. “Tianeptine is a highly addictive drug and the withdrawals are very severe,” said Major Clay Hammac with Shelby County Sheriff’s Office.

Is tianeptine legal in Georgia?

WEST POINT — A drug marketed as a dietary supplement has been outlawed in Alabama, but it’s still available for purchase in Georgia. Tianeptine is often sold under the brand names Tianaa and ZaZa.

What’s in ZaZa red?

Za Za Red 15ct

  • Proprietary Blend 700mg.
  • Combretum Quandrangulare Leaf.
  • Piper Methysticum.
  • Tianeptine.
  • 15ct Bottle.
  • Serving Size 1 Capsule.

Is tianeptine banned in Georgia?

Both Michigan and Alabama banned tianeptine. But it’s a problem here in Georgia too. The Georgia Poison Center said it has helped doctors treat 14 tianeptine patients since 2015, half of them in the past two years.

What is Za Za Red Extra Strength?

New Extra Strength ZAZA (Red, Silver, White) Plus is a unique special blend of nootropics that provides alertness and an ability to focus without the crash that you experience with caffeine. Many use ZAZA Red for test taking or that rough day at work when you are tired but must still perform.

How does Zaza red make you feel?

Tianeptine, often marketed as a dietary supplement, is commonly found sold under the names “Tianaa,” ZaZa Red,” and “Tiana Red.” The substance is highly addictive and can give users a euphoric high and unfortunately strong withdrawal symptoms.