# How is sample size determined in animal research?

Suppose sample size calculated by software is 10 animals per group and researcher is expecting 10% attrition then his final sample size will be 11 animals per group (10/0.9 = 11.11). Similarly, for 20% attrition sample size should be divided by 0.8.

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## How is a sample size in research determined?

The sample size references the total number of respondents included in a study, and the number is often broken down into sub-groups by demographics such as age, gender, and location so that the total sample achieves represents the entire population.

## What is the formula for determining sample size?

How to Find a Sample Size Given a Confidence Level and Width (unknown population standard deviation)

1. za/2: Divide the confidence level by two, and look that area up in the z-table: .95 / 2 = 0.475. …
2. E (margin of error): Divide the given width by 2. 6% / 2. …
3. : use the given percentage. 41% = 0.41. …
4. : subtract. from 1.

## How is sample size determined in clinical trials?

The sample size calculation depends on primary end point of a CT. The description of primary study end point should cover whether it is discrete or continuous or time-to-event. Sample size is estimated differently for each of these end points. Sample size is adjusted if primary end point involves multiple comparision.

## What are 3 factors that determine sample size?

In general, three or four factors must be known or estimated to calculate sample size: (1) the effect size (usually the difference between 2 groups); (2) the population standard deviation (for continuous data); (3) the desired power of the experiment to detect the postulated effect; and (4) the significance level.